Author/Authors :
Wanner، نويسنده , , Jutta and Harned، نويسنده , , Andrew M and Probst، نويسنده , , Donald A and Poon، نويسنده , , Kevin W.C and Klein، نويسنده , , Thomas A and Snelgrove، نويسنده , , Kelley A and Hanson، نويسنده , , Paul R، نويسنده ,
Abstract :
A strategy employing both ring-closing metathesis (RCM) and ring-opening metathesis polymerization (ROMP) as routes to synthesizing oligomeric sulfonamides is described. Amino acid-derived α,β-unsaturated γ-sultams, containing either exo-cyclic or γ-endo-cyclic stereogenic centers, are generated via RCM. These sultams undergo stereoselective Diels–Alder reactions to yield endo-norbornenyl sulfonamides as the major diastereomers. Subsequent ROMP rapidly produces sulfonamide-based oligomers.
