Title of article :
Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng
Author/Authors :
Zhang، نويسنده , , Hongjie and Lu، نويسنده , , Zhizhen and Tan، نويسنده , , Ghee T. and Qiu، نويسنده , , Shengxiang and Farnsworth، نويسنده , , Norman R. and Pezzuto، نويسنده , , John M. and Fong، نويسنده , , Harry H.S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf, -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including 1D and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) with an IC50 value of 13.4 μg/mL (11.1 μM).
Keywords :
Araliaceae , Panax ginseng , polyacetyleneginsenoside , HIV
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
