Solid-phase synthesis of sulfamides

A straightforward synthesis of diversely substituted sulfamides is described. The reaction of sulfamoylating agent 1 with solid-phase bound amines to give polymer bound BOC substituted sulfamides is described. Further N-alkylation is achieved under Mitsunobu conditions. Simultaneous deprotection and cleavage of the products leads to unsymmetrically substituted sulfamides.