Author/Authors :
Duncan ، نويسنده , , Sara F. and Williams، نويسنده , , Dudley H and Ainsworth، نويسنده , , Martyn and Martin، نويسنده , , Steven and Ford، نويسنده , , Robert and Wrigley، نويسنده , , Stephen K، نويسنده ,
Abstract :
The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated.