Author/Authors :
Sun، نويسنده , , Chong-Qing and Cheng، نويسنده , , Peter T.W. and Stevenson، نويسنده , , Jay and Dejneka، نويسنده , , Tamara and Brown، نويسنده , , Baerbel and Wang، نويسنده , , Tammy C. and Robl، نويسنده , , Jeffrey A. and Poss، نويسنده , , Michael A.، نويسنده ,
Abstract :
A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.
