Author/Authors :
Kato، نويسنده , , Keisuke and Tanaka، نويسنده , , Maki and Yamamoto، نويسنده , , Yasuhiro and Akita، نويسنده , , Hiroyuki، نويسنده ,
Abstract :
The first example of asymmetric cyclization–carbonylation of cyclic-2-methyl-2-propargyl-1,3-diols 1 catalyzed by palladium(II) with chiral bisoxazolines was investigated. The reaction of 1 in the presence of palladium(II)-chiral ligands/p-benzoquinone in methanol at 0 to −45°C under carbon monoxide atmosphere (balloon) afforded (E)-bicyclic-β-alkoxyacrylates 2 in excellent yields with moderate enantioselectivities.
