Title of article
Vicarious nucleophilic substitution of 1-benzyl-5-nitroimidazole, application to the synthesis of 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one
Author/Authors
Chen، نويسنده , , Bang-Chi and Chao، نويسنده , , Sam T. and Sundeen، نويسنده , , Joseph E. and Tellew، نويسنده , , John and Ahmad، نويسنده , , Saleem، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
2
From page
1595
To page
1596
Abstract
Reaction of 1-benzyl-5-nitroimidazole with carbanion generated from chloroform and potassium tert-butoxide afforded 1-benzyl-4-dichloromethyl-5-nitroimidazole in 72% yield. This vicarious nucleophilic substitution reaction was successfully applied to the synthesis of 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one, an important intermediate in the synthesis of natural and biologically active compounds.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650171
Link To Document