Author/Authors :
Leroux، نويسنده , , Mary-Lorène and Di Giorgio، نويسنده , , Christophe and Patino، نويسنده , , Nadia and Condom، نويسنده , , Roger، نويسنده ,
Abstract :
Considering the promising anti HIV activity displayed by some diPNA-arginine conjugates, a library has been generated to determine the target(s) and mode(s) of action of these presumed multi targets drugs and to optimize the antiviral properties of lead compounds. This library has been prepared using a combinatorial liquid-phase strategy, involving easily available N-protected PNA dimeric backbones as building blocks.
