Title of article
A new synthesis of 3,5-dihydroxy-7-(1-pyrrolyl)-6-heptenoic acids, a family of HMGCoA reductase inhibitors with antifungal activity
Author/Authors
Castro، نويسنده , , Julia and Coter?n، نويسنده , , José M and Fraile، نويسنده , , M.Teresa and Garc??a-Ochoa، نويسنده , , Silvestre and G?mez de las Heras، نويسنده , , Federico and Mart??n-Cuesta، نويسنده , , Antonio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
1851
To page
1854
Abstract
Starting from a 3,5-dihydroxyheptanoic acid derivative, a new synthesis of pyrrole statins that contain a double bond on the dihydroxyacid chain has been developed. Key steps are N-acylamino acid enamide formation through enamine trapping with aromatic acyl chlorides and subsequent münchnone cycloaddition with activated acetylenes.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650375
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