Title of article :
A new synthesis of 3,5-dihydroxy-7-(1-pyrrolyl)-6-heptenoic acids, a family of HMGCoA reductase inhibitors with antifungal activity
Author/Authors :
Castro، نويسنده , , Julia and Coter?n، نويسنده , , José M and Fraile، نويسنده , , M.Teresa and Garc??a-Ochoa، نويسنده , , Silvestre and G?mez de las Heras، نويسنده , , Federico and Mart??n-Cuesta، نويسنده , , Antonio، نويسنده ,
Abstract :
Starting from a 3,5-dihydroxyheptanoic acid derivative, a new synthesis of pyrrole statins that contain a double bond on the dihydroxyacid chain has been developed. Key steps are N-acylamino acid enamide formation through enamine trapping with aromatic acyl chlorides and subsequent münchnone cycloaddition with activated acetylenes.
