• Title of article

    Deoxyribonolactone formation in photoirradiation of 5-bromouracil-containing oligonucleotides by direct C1′ hydrogen abstraction

  • Author/Authors

    Fujimoto، نويسنده , , Kenzo and Ikeda، نويسنده , , Yutaka and Ishihara، نويسنده , , Shigenori and Saito، نويسنده , , Isao، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2002
  • Pages
    3
  • From page
    2243
  • To page
    2245
  • Abstract
    Mechanistic studies on the formation of deoxyribonolactone by UV irradiation of hexamer d(GC1BrUGC)2 (ODN 2a) containing 1′-deuterio-2′-deoxyadenosine 1 was examined. The kinetic isotope effect (kH/kD) for the formation of C1′ oxidation product 3 was 1.7±0.1. ESI-MS of d(pUGC) (7) obtained from the photoreaction of ODN 2a indicated that 1′ deuterium was abstracted by uracilyl-5-yl radical and incorporated into 7 in 96% yield.
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2002
  • Journal title
    Tetrahedron Letters
  • Record number

    1650644

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1650644