Title of article
Full enzymatic synthesis of a precursor of bioactive pentapeptide OGP(10-14) in organic solvents
Author/Authors
Liu، نويسنده , , Ping and Tian، نويسنده , , Gui-ling and Lee، نويسنده , , Kin-Sing and Wong، نويسنده , , Man-Sau and Ye، نويسنده , , Yun-hua، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
2423
To page
2425
Abstract
Full enzymatic synthesis of a fragment of osteogenic growth peptide (OGP), a precursor of bioactive pentapeptide OGP(10-14) (Z-TyrGlyPheGlyGlyOEt), was accomplished by papain, α-chymotrypsin, and thermolysin via 2+3 or 3+2 synthetic routes in organic solvents for the first time. The factors influencing the enzymatic synthesis of fragments of OGP(10-14) were systematically studied.
Keywords
OGP(10-14) , Organic solvent , protease , full enzymatic synthesis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650781
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