Title of article :
Enantioselective lipase-catalyzed reactions of methyl pipecolinate: transesterification and N-acylation
Author/Authors :
Liljeblad، نويسنده , , Arto and Lindborg، نويسنده , , Jutta and Kanerva، نويسنده , , Anu and Katajisto، نويسنده , , Johanna and Kanerva، نويسنده , , Liisa T. Kanerva، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
The present research introduces the highly (S)-selective (E>>100) acylation at the secondary ring nitrogen of methyl pipecolinate as a novel resolution method with Candida antarctica lipase A. Catalysis by lipase B leads to reactions at the methyl ester function of the substrate in an almost non-enantioselective manner.
Keywords :
RESOLUTION , Candida antarctica lipase A , Candida antarctica lipase B , Pipecolic acid , methyl pipecolinate
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
