Title of article :
Development of 5-(aminomethyl)pyrrole-2-carboxylic acid as a constrained surrogate of Gly-ΔAla and its application in peptidomimetic studies
Author/Authors :
Chakraborty، نويسنده , , Tushar K and Krishna Mohan، نويسنده , , B and Kiran Kumar، نويسنده , , S and Kunwar، نويسنده , , Ajit C، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
A new peptidomimetic scaffold based on 5-(aminomethyl)pyrrole-2-carboxylic acid (1) is developed for the first time and used as a conformationally constrained surrogate of the Gly-ΔAla dipeptide isostere (2) to prepare peptides 3 and 4.
Keywords :
Dehydro amino acids , peptide mimetics , Hydrogen bonding , Conformation , NMR
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
