Author/Authors :
Cavicchioli، نويسنده , , Marcello and Marat، نويسنده , , Xavier and Monteiro، نويسنده , , Nuno and Hartmann، نويسنده , , Beno??t and Balme، نويسنده , , Geneviève، نويسنده ,
Abstract :
A large array of 3-methylene tetrahydrofurans has been synthesized from propargylic alcohols and activated olefins. The reaction is promoted by copper iodide that is removed at the end of the reaction by simple filtration, affording the desired heterocycles in high yield and purity.
Keywords :
Solution-phase synthesis , Combinatorial chemistry , Copper catalysis , tetrahydrofurans
