Title of article :
The first total synthesis of iPF4α-VI and its deuterated analog
Author/Authors :
Kim، نويسنده , , Seongjin and Lawson، نويسنده , , John A. and Praticٍ، نويسنده , , Domenico and FitzGerald، نويسنده , , Garret A. and Rokach، نويسنده , , Joshua، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
The total and stereospecific syntheses of iPF4α-VI and d4-iPF4α-VI have been accomplished. iPF4α-VI is a docosahexanenoic acid (DHA)-derived isoprostane. DHA is the most abundant polyunsaturated fatty acid in the brain. Different synthetic designs have been used for the two syntheses. In the d4-iPF4α-VI design, the deuterated part of the molecule was introduced last in the synthesis.
Keywords :
Isoprostanes , IP , Arachidonic acid , Docosahexaenoic acid , AA , DHA , iPF4?-VI , d4-iPF4?-VI
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
