Total synthesis of (+)-herbarumin I via intermolecular Nozaki–Hiyama–Kishi reaction

The phytotoxin herbarumin I, isolated from Phoma herbarum, was stereoselectively synthesized in 17 steps and 6% yield from l-arabinose featuring the intermolecular Nozaki–Hiyama–Kishi coupling and modified Yamaguchi macrolactonization as key steps.