Stereospecific preparation of (Z)-α-fluorostilbenes via a kinetically controlled palladium-catalyzed cross-coupling reaction of high E/Z ratio 1-bromo-1-fluorostyrenes and aryl stannanes

High E/Z ratios were obtained for 1-bromo-1-fluorostyrenes by isomerization from the original E/Z ratios of approximately 1:1. The palladium-catalyzed cross-coupling reaction of high E/Z ratio 1-bromo-1-fluorostyrenes with aryl stannanes gives (Z)-α-fluorostilbenes stereospecifically in good yields.