Title of article
Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning
Author/Authors
Yabu، نويسنده , , Kazuo and Masumoto، نويسنده , , Shuji and Kanai، نويسنده , , Motomu and Curran، نويسنده , , Dennis P. and Shibasaki، نويسنده , , Masakatsu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
2923
To page
2926
Abstract
Enantioselective catalyst efficiency for the synthesis of the camptothecin family was improved through ligand-tuning. Key intermediates of two convergent syntheses of camptothecin (Curranʹs intermediate and Coreyʹs intermediate) were obtained in up to 10 g scale through the catalytic enantioselective cyanosilylation of ketones.
Keywords
camptothecin , chiral ligand , catalytic enantioselective reaction , Cyanosilylation , ketones , ligand-tuning , Catalyst loading
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1651140
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