Author/Authors :
Ami، نويسنده , , Eiʹichi and Rajesh، نويسنده , , S and Wang، نويسنده , , Jung and Kimura، نويسنده , , Tooru and Hayashi، نويسنده , , Yoshio and Kiso، نويسنده , , Yoshiaki and Ishida، نويسنده , , Toshimasa، نويسنده ,
Abstract :
Novel amino acids, enantiomerically pure l-bis-tetrahydrofuranylglycines, were efficiently synthesized from dihydrofuran utilizing radical cyclization and chiral azidation as the key steps. The absolute stereochemistry of both diastereomers has been ascertained by their crystal structures.
Keywords :
HIV-1 protease , HIV-1 protease inhibitor , radical cyclization , novel amino acid
