Title of article
Diastereoselective and enantioselective lipase-catalyzed hydrolysis of stereoisomeric 2-methylene, 5-t-butylcyclohexyl acetates
Author/Authors
Bidjou، نويسنده , , Chahra and Aribi-Zouioueche، نويسنده , , Louisa and Fiaud، نويسنده , , Jean-Claude، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
3025
To page
3027
Abstract
cis- and trans-2-Methylene-5-t-butylcyclohexanols are obtained in high (>90%) e.e. through Rabbit Gastric Lipase (RGL)-catalyzed acylation or hydrolysis of the stereoisomeric racemic alcohols or their corresponding acetates. Since these reactions were diastereomer-selective, enantiomerically enriched cis- and trans-5-t-butyl-2-methylenecyclohexanols could also be prepared from cis/trans isomeric mixtures.
Keywords
kinetic resolution , Enzyme , enantioselective , Hydrolysis , acylation , Catalysis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1651220
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