Author/Authors :
Millo، نويسنده , , Enrico and Nicolai، نويسنده , , Raffaele and Scarfi’، نويسنده , , Sonia and Scapolla، نويسنده , , Carlo and Biasotti، نويسنده , , Barbara and Benatti، نويسنده , , Umberto and Damonte، نويسنده , , Gianluca، نويسنده ,
Abstract :
A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protected cystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bond formation in this kind of oligomers, which are traditionally obtained by liquid phase coupling via oxidation of the two terminal cysteines.
