Author/Authors :
Sollogoub، نويسنده , , Matthieu and Fox، نويسنده , , Keith R. and Powers، نويسنده , , Vicki E.C. and Brown، نويسنده , , Tom، نويسنده ,
Abstract :
The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides.
