Title of article :
Chemical versus enzymatic acetylation of α-bromo-ω-hydroxyaldehydes: decyclization of hemiacetals by lipase
Author/Authors :
O. Villoʹ، نويسنده , , Ly and Metsala، نويسنده , , Andrus and Parve، نويسنده , , Omar and Pehk، نويسنده , , Tُnis، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
Lipase-catalyzed decyclization of hemiacetals of α-bromo-ω-hydroxyaldehydes followed by trapping upon acetylation was observed. Quantum chemical investigations were performed to explain the energetic background of the reactions. The stereocontrolled synthesis of enantiopure trans-(2S,3S)-2-methoxy-tetrahydropyran-3-ol was elaborated.
Keywords :
Lipase , deoxysugar alkyl glycoside , decyclization of hemiacetal by lipase , ?-bromo-?-hydroxyaldehyde
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
