Title of article
Mono N-arylation of piperazine(III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate
Author/Authors
Hepperle، نويسنده , , Michael and Eckert، نويسنده , , Jeffrey and Gala، نويسنده , , Dinesh and Shen، نويسنده , , Lan and Anderson Evans، نويسنده , , C and Goodman، نويسنده , , Andrew، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
3359
To page
3363
Abstract
A novel application of Pd0-catalyzed arylation to mono N-arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N,N′-diarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N′-(4-aminophenyl)piperazine 5 as well as posaconazole 1 are described.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1651451
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