Title of article :
Total synthesis of the antitumor agent (−)-laulimalide
Author/Authors :
Mulzer، نويسنده , , Johann and Hanbauer، نويسنده , , Martin، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
A stereocontrolled synthesis of the title compound is described. Key steps are an allylsilane addition to a chiral acetal as the major coupling step and a Yamaguchi macrolactonization for ring closure.
Keywords :
Marine metabolites , macrolactonization , allylsilane addition , chiral acetal , Antitumor compounds
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
