A convenient synthesis of chiral dioxocyclens and application as chiral solvating agents

This paper reports a very short and efficient synthesis of chiral dioxocyclens starting from natural amino acids. NMR experiments were undertaken to assess the chiral recognition properties of these chiral macrocycles. The NMR spectra of mandelic acid or its derivatives in the presence and absence of the chiral dioxocyclens showed that these macrocycles have different enantiomeric discriminating ability. It was revealed that this type of dioxocyclen may be promising hosts for chiral discrimination.