Totally diastereoselective synthesis of a new chiral quinoline diazaphospholidine ligand and its derivatives

QUIPHOS-PN5, a new stable P,N ligand with a stereogenic phosphorus centre was synthesised in two steps from 8-bromoquinoline (61% yield). Its structure and its bidentate chelating ability was confirmed by the X-ray structure of a palladium(II) complex with this ligand. P(V) derivatives of QUIPHOS-PN5 were then easily obtained in excellent yields (85–100%).