Title of article
A new synthesis of 2-nitroindoles
Author/Authors
Jiang، نويسنده , , Jun and Gribble، نويسنده , , Gordon W، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
4115
To page
4117
Abstract
The C-2 lithiation of N-Boc- and N-(phenylsulfonyl)indoles (4–7) followed by reaction with dinitrogen tetroxide at low temperature affords the corresponding 2-nitroindoles 10–13 in 63–78% yields. Deprotection of the N-Boc-2-nitroindoles (10, 11) with trifluoroacetic acid gives 2-nitroindole (3) and 3-methyl-2-nitroindole (14) in essentially quantitative yields.
Keywords
N2O4 , Nitration , 2-nitroindoles , Dinitrogen tetroxide , 2-lithioindoles
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652004
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