Title of article
A useful conversion of alcohols to alkyl fluorides
Author/Authors
Flosser، نويسنده , , David A and Olofson، نويسنده , , Roy A، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
4275
To page
4279
Abstract
A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120–125°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652114
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