Author/Authors :
Williams، نويسنده , , David R. and Mi، نويسنده , , Liang and Mullins، نويسنده , , Richard J. and Stites، نويسنده , , Ryan E.، نويسنده ,
Abstract :
An enantioselective synthesis of (−)-laulimalide is described. Key reactions include a convergent allylation coupling reaction, asymmetric conjugate addition, the allenylstannane Ferrier reaction and a chelation-controlled alkenylzinc addition as the basis for stereocontrol in critical elements of chirality.