Author/Authors :
Semmelhack، نويسنده , , M.F. and Jaskowski، نويسنده , , Mark and Sarpong، نويسنده , , Richmond and Ho، نويسنده , , Douglas M.، نويسنده ,
Abstract :
A synthesis of a simple trans fused [8.3.0]bicyclic enediyne framework was developed from cyclopentanone-trans-3,4-dicarboxylate. The rates of rearrangement of several derivatives of the framework were measured, and correlated with structural features. Preliminary studies to adjust the configuration about the ring fusion, expected to be an activation step, are discussed.
