An efficient solid-phase synthesis of 3-alkylamino-1,2,4-oxadiazoles

A solid-phase synthesis of substituted 3-alkylamino-1,2,4-oxadiazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydroxylamine under mild conditions furnished the oxadiazole skeleton regioselectively in high yield and purity.