Author/Authors :
Wiese، نويسنده , , Kevin J and Yakushijin، نويسنده , , Kenichi and Horne، نويسنده , , David A، نويسنده ,
Abstract :
A short synthesis of the marine sponge alkaloids dibromophakellstatin (1) and dibromoisophakellin (2) is described. The synthesis of 1 centers on a putative biomimetic oxidative cyclization of imidazolone 5. Thermal rearrangement of dibromophakellin (9) in the presence of K2CO3 afforded dibromoisophakellin (2).
