Title of article
Zinc-mediated Barbier reactions of pyrrole and indoles: a new method for the alkylation of pyrrole and indoles
Author/Authors
Yadav، نويسنده , , J.S. and Reddy، نويسنده , , B.V.S. and Reddy، نويسنده , , P.Muralikrishna and Srinivas، نويسنده , , Ch.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
5185
To page
5187
Abstract
Pyrrole and indoles react smoothly with alkyl halides such as allyl bromide, prenyl bromide, crotyl bromide and propargyl bromide in the presence of zinc metal in THF to afford the corresponding 3- and 2-alkyl pyrrole and 3-alkyl indole derivatives in good yields with high regioselectivity.
Keywords
organozinc reagents , Barbier reaction , C-alkylation of heterocycles
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652753
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