A straightforward strategy toward the construction of polypropionate frameworks, based on a sequence of diastereoselective Lewis acid-mediated aldol reaction and diastereoselective radical debromination reaction

An approach joining highly diastereoselective Mukaiyama aldol reaction (process A) to the following radical debromination reaction (process B) provides a reliable way to the stereoselective divergent synthesis of polypropionate frameworks. A practical and reliable synthesis of the complete set of propionate stereotetrads from enantiopure syn- and anti-2-methyl-3-methoxy-3-phenylpropanals was achieved by using the straightforward strategy.