Author/Authors :
Nawrot، نويسنده , , B and Michalak، نويسنده , , O and Nowak، نويسنده , , Andrzej Okruszek، نويسنده , , A and Dera، نويسنده , , M and Stec، نويسنده , , W.J، نويسنده ,
Abstract :
Novel analogues of acyclic nucleosides based on a bis(hydroxymethyl)phosphinic acid (BHPA) backbone were obtained by condensation of the bis(4,4′-dimethoxytrityl) derivative of BHPA with N-1- or N-3-(2-hydroxyethyl)thymine in the presence of MSNT, or by an Appel reaction with N-1- or N-3-(2-aminoethyl)thymine. After selective deprotection and phosphitylation they were used as monomers for automated solid support synthesis of short oligomers by the phosphoramidite approach.
