Author/Authors :
OBrien، نويسنده , , Matthew and Taylor، نويسنده , , Nicholas H and Thomas، نويسنده , , Eric J، نويسنده ,
Abstract :
A synthesis of the C(1)C(16) fragment 43 of the bryostatins is reported which features a stereoselective equivalent of an ‘ene’ reaction between the allylsilane 35 and the alkynone 33 and the stereoselective conjugate addition–cyclisation of the dienyl ketone 36 to give the acetal 39 after acetalisation.
