Author/Authors :
Kesarwani، نويسنده , , A.P. and Srivastava، نويسنده , , G.K. and Rastogi، نويسنده , , S.K and Kundu، نويسنده , , B.، نويسنده ,
Abstract :
A versatile method for the solid-phase synthesis of differentially substituted quinazolin-4(3H)-ones has been developed using immobilized arylguanidines. The latter were obtained by treating the amino group of polymer-linked anthranilamide with isothiocyanates followed by coupling with secondary amines in the presence of DIC. Finally a cyclative cleavage strategy was applied to give the desired compounds in high yields and purities.
