Title of article
A one-pot esterification of chiral O-trimethylsilyl-cyanohydrins with retention of stereochemistry
Author/Authors
Norsikian، نويسنده , , Stephanie and Holmes، نويسنده , , Ian and Lagasse، نويسنده , , Franz and Kagan، نويسنده , , Henri B، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
5715
To page
5717
Abstract
Enantiomerically enriched O-TMS cyanohydrins have been transformed directly into O-acyl-cyanohydrins using various anhydrides or acid chlorides in the presence of catalytic amounts of scandium(III) triflate. The reaction occurs with full retention of stereochemistry and allows the convenient measurement of enantiomeric excesses by chiral HPLC.
Keywords
ee measurement , Scandium triflate , Esterification , O-trimethylsilyl-cyanohydrins , O-acyl-cyanohydrins
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1653090
Link To Document