Author/Authors :
Takahashi، نويسنده , , Hiroyasu and Kashiwa، نويسنده , , Nobuyuki and Kobayashi، نويسنده , , Hisayoshi and Hashimoto، نويسنده , , Yuichi and Nagasawa، نويسنده , , Kazuo، نويسنده ,
Abstract :
Substitution reaction of 4-hydroxymethylaniline derivatives with resonance-stabilized carbon nucleophiles and an acid-labile nucleophile, including β-ketoester, 1,3-diketone, α-nitroester, and silylenolether, proceeded efficiently upon heating at 80°C in a neutral solvent system. The reaction was successfully applied to the synthesis of 4-aminophenylalanine.
