Title of article
Nucleophilic substitution on 4-hydroxymethylanilines under ‘neutral’ conditions via aza quinone methide intermediate
Author/Authors
Takahashi، نويسنده , , Hiroyasu and Kashiwa، نويسنده , , Nobuyuki and Kobayashi، نويسنده , , Hisayoshi and Hashimoto، نويسنده , , Yuichi and Nagasawa، نويسنده , , Kazuo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
5751
To page
5753
Abstract
Substitution reaction of 4-hydroxymethylaniline derivatives with resonance-stabilized carbon nucleophiles and an acid-labile nucleophile, including β-ketoester, 1,3-diketone, α-nitroester, and silylenolether, proceeded efficiently upon heating at 80°C in a neutral solvent system. The reaction was successfully applied to the synthesis of 4-aminophenylalanine.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1653115
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