Author/Authors :
Cheng، نويسنده , , Jie-Fei and Chen، نويسنده , , Mi and Arrhenius، نويسنده , , Thomas and Nadzan، نويسنده , , Alex، نويسنده ,
Abstract :
An extremely efficient synthesis of Δ5-2-oxopiperazines in solution phase and on solid support has been established via a Ugi four-component condensation reaction (U-4CC) followed by N-acyliminium ion cyclization between the aldehyde (acetal) functionality and the newly formed amide bond. The desired Δ5-2-oxopiperazines are obtained in excellent yields and purity.
