Microwave activated solvent-free cascade reactions yielding highly functionalised 1,3-thiazines

One-pot cascade reactions of N-acylglycines, acetic anhydride, anhydrous sodium acetate, aromatic aldehydes, and ammonium N-aryldithiocarbamates expeditiously and diastereoselectively yield 5-acylamino-3,6-diarylperhydro-2-thioxo-1,3-thiazin-4-ones (5a–j) in solvent-free conditions under microwave irradiation.