Title of article :
Novel syntheses of the amino-1,2,4-triazine GW356194: identification of a synthesis amenable to scale up
Author/Authors :
Adam، نويسنده , , Fiona M. and Burton، نويسنده , , Andrew J. and Cardwell، نويسنده , , Kevin S. and Cox، نويسنده , , Richard A. and Henson، نويسنده , , Richard A. and Mills، نويسنده , , Keith and Prodger، نويسنده , , Jeremy C. and Schilling، نويسنده , , Mark B. and Tape، نويسنده , , Daniel T.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
New syntheses of the amino-1,2,4-triazine, GW356194 have been developed to improve on existing methodology. The use of different amidrazones in cyclisations with α-keto and α-amido carbonyl compounds as the key step for the synthesis of the 1,2,4-triazine core was evaluated and the results are presented here.
Keywords :
1 , 2 , 1 , 2 , 4-triazinone , amidrazone , thiosemicarbazide , formamidrazone , ethyl oxamidrazonate , 4-triazine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
