Title of article
Catalytic enantioselective conjugate addition of indoles to simple α,β-unsaturated ketones
Author/Authors
Bandini، نويسنده , , Marco and Fagioli، نويسنده , , Matteo and Melchiorre، نويسنده , , Paolo and Melloni، نويسنده , , Alfonso and Umani-Ronchi، نويسنده , , Achille، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
5843
To page
5846
Abstract
Chiral [Al(salen)Cl] complex (10 mol%) in the presence of 2,6-lutidine (10 mol%) was found to be effective in catalysing the enantioselective Friedel–Crafts-type conjugate addition of indoles (3) to (E)-arylcrotyl ketones (2), furnishing the corresponding β-indolyl ketones in excellent yield and high enantioselectivity (ee up to 89%).
Keywords
Aluminium , Asymmetric catalysis , indole , ketones , Michael reaction
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1653722
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