Author/Authors :
Sanjayan، نويسنده , , Gangadharar J. and Stewart، نويسنده , , Alistair and Hachisu، نويسنده , , Shuji and Gonzalez، نويسنده , , Raquel and Watterson، نويسنده , , Mark P. and Fleet، نويسنده , , George W.J. Fleet، نويسنده ,
Abstract :
Short syntheses of enantiomeric templated scaffolds of cis- and trans-tetrahydrofuran γ-amino acids from pentono-δ-lactones derived from arabinose and ribose are reported; an unexpectedly efficient synthesis of a templated tetrahydrofuran β-amino acid by azide displacement of a triflate β to an ester function proceeds with remarkably little elimination. These materials should allow evaluation of such peptidomimetics to induce predisposition towards secondary structures.
