Author/Authors :
Avallone، نويسنده , , Elvira and Izzo، نويسنده , , Irene and Vuolo، نويسنده , , Gerardo and Costabile، نويسنده , , Monica and Garrisi، نويسنده , , Davide and Pasquato، نويسنده , , Lucia and Scrimin، نويسنده , , Paolo and Tecilla، نويسنده , , Paolo and De Riccardis، نويسنده , , Francesco، نويسنده ,
Abstract :
A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized l-treitol spacer two rigid hydrophobic 3β-hydroxy-5α-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport.
