Author/Authors :
Tu، نويسنده , , Shujang and Fang، نويسنده , , Fang and Miao، نويسنده , , Chunbao and Jiang، نويسنده , , Hong and Feng، نويسنده , , Youjian and Shi، نويسنده , , Daqing and Wang، نويسنده , , Xiangshan، نويسنده ,
Abstract :
A simple effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives, using boric acid as catalyst, from aromatic aldehydes, 1,3-dicarbonyl compounds and urea in glacial acetic acid is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (86–97%) and short reaction time (0.5–2 h).
