Author/Authors :
Ahaidar، نويسنده , , Abderaouf and Fernلndez، نويسنده , , David and Pérez، نويسنده , , Olga and Danelَn، نويسنده , , Gerardo and Cuevas، نويسنده , , Carmen and Manzanares، نويسنده , , Ignacio and Albericio، نويسنده , , Fernando and Joule، نويسنده , , John A. and ءlvarez، نويسنده , , Mercedes، نويسنده ,
Abstract :
The total synthesis of variolin B from 4-methoxy-7-azaindole is described. The preparation of the protected amino derivative 10 and a coupling reaction of the iodo derivative 12 with 2-acetylamino-4-trimethylstannylpyrimidine are the key steps of the sequence. The use of N-tosyldichloromethanimine for the cyclisation step afforded a good entry to the 9-aminopyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine system. Variolin B was obtained from the triply protected tetracyclic compound 13 in two steps.
