Liquid-phase synthesis of 2,3-dihydro-4-pyridones: one-pot three-component aza Diels–Alder reaction of Danishefskyʹs diene with aldehydes and PEG-supported amine

An efficient liquid-phase synthesis technique for the construction of 2,3-dihydro-4-pyridones on soluble polymer support has been developed, which utilized one-pot reaction of Danishefskyʹs diene with aldehydes and polymer-supported amine.