Author/Authors :
Saksena، نويسنده , , Anil K. and Girijavallabhan، نويسنده , , Viyyoor M. and Puar، نويسنده , , Mohindar S. and Pramanik، نويسنده , , Birendra N. and Das، نويسنده , , Pradip R. and McPhail، نويسنده , , Andrew T.، نويسنده ,
Abstract :
Treatment of (2S,3R)-2,3-O-isopropyliden-4-penten-1,2,3-triol mesylate with uracil, K2CO3 did not provide the product of SN2 displacement, but an interesting acetonide group migration product 8. The structure of 8 was secured by spectral analysis and single crystal X-ray analysis. The desired product 2 could be ultimately obtained by Mitsunobu reaction of the alcohol 6 with 3-N-benzoyl uracil followed by basic hydrolysis.
